Penile PRP Injections

Medically reviewed by David Shusterman, MD · Updated September 11, 2026

Penile PRP is an injection of your own platelet-rich plasma into the penis. A small amount of blood is drawn, spun in a centrifuge to concentrate the platelets and the growth factors they carry, and the concentrate is injected into the shaft under local anesthesia. The idea is that those growth factors encourage repair of small blood vessels and tissue, and that the volume of the injection itself adds some girth. The branded version of this procedure is the Priapus Shot, or P-Shot, which we also offer; this page covers PRP for the penis more generally, including what it can and cannot do.

We want to be straightforward about the evidence. It is limited. There are small studies suggesting benefit for erectile function and a plausible mechanism, but there are no large, well-controlled trials, and the results reported by clinics are often more enthusiastic than the data supports. What we can say from our own patients is this: PRP adds a little size, and men report stronger and longer-lasting erections afterward. The gains are modest. If you come in expecting a transformation you will be disappointed, and we would rather tell you that now.

Who it affects and the symptoms that bring people in

Men ask about penile PRP for two reasons. The first is erectile function: erections that are softer, less reliable, or shorter-lived than they used to be, often in men who do not want to depend on pills or who get side effects from them. The second is size, usually girth, in men who are within the normal range but would like more.

For girth, it is worth knowing what else is on the market and why we do not offer it. Fat transfer, in which fat is harvested from the abdomen and injected into the penis, produces a result that in our view looks puffy and unnatural, and the fat is absorbed unevenly over time, sometimes leaving lumps. Dermal fillers carry similar problems in this location. PRP does not add nearly as much volume as fat, but it is your own blood, it integrates into the tissue rather than sitting in it, and it does not leave you with a shape you did not want. Cosmetic Botox to the scrotum, sometimes marketed alongside these procedures, is something we decline to do.

How we evaluate it at NYMD Center

A man who comes in for PRP because of erectile dysfunction gets an erectile dysfunction evaluation, not just an injection. That matters because ED is often the first visible sign of narrowing in the small arteries, and it can precede heart disease by years. The visit includes a history, an examination, and blood work that covers glucose, lipids and testosterone. We check blood pressure. Where the history suggests vascular disease, we arrange heart and stroke risk screening through our internal medicine and cardiology colleagues in the same building. If the picture is unclear, a penile duplex ultrasound in the office measures blood flow into and out of the penis and tells us what kind of ED we are dealing with.

For men whose interest is size, the evaluation is shorter, but we still examine you, review your medications and bleeding history, and have an honest conversation about expectations. We also check for Peyronie's plaques, since scar tissue changes the plan.

Treatment options

PRP injection

The procedure takes about 45 minutes in the office, most of it spent preparing the plasma. A numbing cream is applied, blood is drawn from your arm and spun, and the PRP is injected at several points along the shaft with a fine needle. Discomfort is brief. Bruising and mild swelling for a few days are common; there is no downtime, and sexual activity can resume within a day or two. Some men have a single treatment; others do a short series a few weeks apart, and the effect, where there is one, is generally described over the following one to three months. Because it is your own blood, allergic reaction is not a concern, and infection is rare with sterile technique.

Other approaches to erectile function

For men with vascular ED, low-intensity shockwave therapy has a similar goal, improving blood flow, with a somewhat larger body of evidence behind it, and the two are sometimes combined. Oral medications remain the most reliable first-line treatment for most men. Trimix injections work when pills do not. Penile implants are the definitive option for severe ED. PRP sits alongside these as an adjunct for men with mild to moderate ED who want to try something that may improve the underlying tissue, not as a replacement for them.

What we do not offer for size

We do not perform fat transfer to the penis, and we do not inject synthetic fillers into it, for the reasons above. For men whose concern is size, we also discuss the range of normal, because many men who ask are entirely within it, and the most useful thing we can offer is that information.

What to expect at your visit

Your first visit is a consultation. Bring a list of medications and supplements; blood thinners and high-dose fish oil or vitamin E increase bruising and may need to be paused. If PRP is appropriate and you decide to proceed, the injection can often be done at a second visit or, for men who have already completed an evaluation, the same day. You will be in the office for under an hour, can drive yourself home, and will be given simple aftercare: no sex for a day or two, no vigorous activity that day, and a call to us if swelling or pain is more than mild. We see you back in a few months to review what has changed and whether a further treatment makes sense.

PRP is not covered by insurance and is paid out of pocket. Our staff will give you the cost before you commit to anything.