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The Effects of Excessive Protein: Separating Fact from Fiction

Medically reviewed by Yulya Timashpolsky, MD, board-certified internist · Reviewed September 29, 2026

The Effects of Excessive Protein: Separating Fact from Fiction

17 Aug The Effects of Excessive Protein: Separating Fact from Fiction

Posted at 17:36h in Uncategorized by NYMD0 Likes

The Effects of Excessive Protein: Separating Fact from Fiction

Protein is an essential nutrient that our body needs for various functions, including muscle growth, hormone production, and cell repair. It is no wonder that high-protein diets have gained popularity in recent years, with proponents claiming that it can lead to a better physique and improved mental clarity. However, is it possible to have too much of a good thing? In this blog post, we will explore the effects of excessive protein intake and separate fact from fiction.

According to Dr. David Shusterman, a renowned urologist at NY Urology in New York City, most individuals do not meet the criteria for excess protein intake and can consume moderately more than the recommended dietary allowance (RDA) without adverse effects. However, consuming more than 3 grams of protein per kilogram of body weight is considered excessively high and not recommended for long-term consumption.

One common concern associated with excessive protein intake is constipation. High-protein diets often encourage replacing carbohydrates with protein, which can lead to diminished fiber intake. Insufficient fiber can result in gastrointestinal issues such as constipation.

Another potential consequence of excessive protein consumption is dehydration. Breaking down large amounts of protein increases the waste the kidneys must flush out in urine, which raises your need for water; if you don’t drink enough, this can contribute to dehydration. Dehydration can manifest as various symptoms, including headaches, fatigue, dizziness, and yes, even constipation.

Some concerns associated with high-protein diets relate to specific organs, such as the kidneys and liver. High-protein diets do not appear to harm kidney function in healthy individuals, but they can put additional strain on already compromised kidneys. This strain occurs when damaged kidneys have to work harder to filter waste products produced during protein metabolism, such as nitrogen. If you have kidney disease, diabetes, or high blood pressure, talk with your doctor about your kidney function before starting a high-protein diet.

The liver also plays a crucial role in breaking down protein, and excess calories or alcohol can strain the liver. However, there is no good evidence that a high-protein diet by itself causes liver damage or liver disease in healthy people. Anyone with existing liver disease should have their protein intake guided by their doctor.

The effects of high-protein diets on hormone levels are another point of consideration. Some studies suggest that extremely high protein intakes (above about 3.4 grams per kilogram of body weight per day) may lower testosterone levels, while more typical high-protein diets do not appear to. Low testosterone can affect men’s health, including sexual health, libido and fertility.

Research has also suggested a potential link between high-protein diets and an increased risk of certain types of cancer. Diets high in red and processed meats, in particular, have been associated with colorectal cancer, and possibly with prostate and pancreatic cancer. On the other hand, proteins from plant-based sources, eggs, and dairy may be linked to a decreased risk of cancer.

In conclusion, while protein is an essential nutrient, excessive protein intake can have adverse effects on various aspects of health. It is crucial to strike a balance: current U.S. Dietary Guidelines suggest about 1.2–1.6 grams of protein per kilogram of body weight per day for most adults, while people with chronic kidney disease should follow their doctor’s lower target. A diverse and balanced diet that includes sources of high-quality protein, such as lean meats, fish, eggs, and plant-based proteins, is recommended. Additionally, incorporating other macronutrients, staying hydrated, and maintaining a healthy lifestyle are key components of safely following a high-protein diet.

To learn more, you can read the full article at: https://getmegiddy.com/too-much-protein-constipation

Sources

  1. Dietary Guidelines for Americans, 2025–2030. U.S. Department of Agriculture / U.S. Department of Health and Human Services, 2026.
  2. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. National Academies (Institute of Medicine), 2005.
  3. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int, 2024.
  4. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr, 2017.
  5. Changes in Kidney Function Do Not Differ between Healthy Adults Consuming Higher- Compared with Lower- or Normal-Protein Diets: A Systematic Review and Meta-Analysis. J Nutr, 2018.
  6. Dietary protein intake and human health. Food Funct, 2016.
  7. High-protein diets and testosterone. Nutr Health, 2023.
  8. Carcinogenicity of consumption of red and processed meat. Lancet Oncol (IARC Monographs Working Group), 2015.